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Nature INDEX 2016 JAPAN

Nature INDEX 2016 JAPAN
Papers published in 2016 and Chubu University's position among Japanese research institutions

The Nature Index is a database that profiles the world's leading research achievements by country and institution.
It contains scientific papers published in a select group of academic journals.
The Nature Index 2016 Japan contains the fpapers listed here, produced by researchers at Chubu University.

  • Among all institutions: 73rd position
  • Among private universities: 14th position
  • Among universities in Tokai region (Aichi, Gifu, and Mie): 5th position
    * After Nagoya University, Nagoya Institute of Technology, Gifu University, and Nagoya City University

YAMAMOTO Hisashi, Professor (Institute of Science and Technology Research/Molecular Catalyst Research Center)

Listed Papers

  1. Catalytic Asymmetric Synthesis of N-Chiral Amine Oxides
  2. A Powerful Chiral Phosphoric Acid Catalyst for Enantioselective
  3. Hydroxy-Directed Amidation of Carboxylic Acid Esters Using a Tantalum Alkoxide Catalyst
  4. A Disulfonimide Catalyst for Highly Enantioselective Mukaiyama-Mannich Reaction

Previously unsuccessful conversion processes, such as the synthesis of diverse catalytic carbon skeletons, carbon-nitrogen bonding reaction, and various oxidation-reduction reactions, have been successfully performed. In particular, the "Hydroxy-Directed Amidation of Carboxylic Acid Esters Using a Tantalum Alkoxide Catalyst" (3.) represents a new concept of organic synthesis that we proposed, and it which is expected to be widely used in the future as a core concept of synthetic reaction development in Japan and abroad. Hydroxy-directed chemical reaction represents a fundamental concept of general enzyme reactions, so to speak. Hydroxy-directed amidation is a technique that applies hydroxy-directed chemical reaction to organic synthesis while excluding the specificity associated with enzyme reaction, keeping the wide generality of organic synthesis intact. Hydroxy-directed amidation is a concept that is beginning to lead future organic synthesis. The use of this concept in catalyst design has led to partial success in meeting the heretofore unsolved difficult challenge of catalytic peptide synthesis free of isomerization.



FURUKAWA Koichi, Professor (College of Life and Health Sciences/Research Institute of Life and Health Sciences)
FURUKAWA Keiko, Professor (College of Life and Health Sciences)

Listed Papers

  1. Neogenin defined as a GD3-associated molecule by the enzyme-mediated activation of radical sources confers malignant properties via the intracytoplasmic domain in melanoma cells
  2. Raft-based interactions of gangliosides with a GPI-anchored receptor
  3. Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis

Glycolipids in cell membranes control signals that can cause cancers and nerve degeneration.

Glycoproteins and glycolipids that occur in cell membranes transmit environmental insults to within cells. These various sugar chains that are bound to membrane molecules function to maintain cells in response to various changes in their environment. Malignant melanoma, or cancer in moles, characteristically causes glycolipid GD3 to occur, although the role of GD3 has been unclear. The authors' findings show that GD3 is bound to neogenin on the cell membrane, by which the cytoplasmic part of the neogenin migrates into the nucleus and facilitates the manifestation of many genes. Moreover, as revealed by high-resolution observation in the order of milliseconds, these glycolipids function by forming two to several multimeric complexes in the domain, known as a "raft," which floats on the cell membrane. Both are new discoveries enabled by full use of the latest analysis technology. Meanwhile, as antibodies, which are important for living organisms to protect themselves, bind to one sugar chain, it has been found that the pathogenicity of the antibody largely depends on whether or not it is a sialic acid-containing sugar chain. This is extremely important information for controlling cancer and inflammation in the future.



SHIBATA Shoichi, Professor (College of Engineering)
OSHIMA Akitoshi, Associate Professor (College of Engineering)
KOJIMA Hiroshi, Visiting Professor (Chubu Innovative Astronomical Observatory)

Listed Paper

  1. Transient Weakening of Earth's Magnetic Shield Probed by a Cosmic Ray Burst

We are continuously observing cosmic rays in an international joint research program using equipment installed in various parts of the globe and on artificial satellites. The purposes of this research are to clarify the origin of cosmic radiation, its acceleration and propagation mechanisms, and the interaction of elementary particles in the ultrahigh-energy region, and to monitor the electromagnetic and radiation environment in the space around the Earth involving solar activity. On June 22, 2015, GRAPES-3, an observatory system installed in South India, captured a low-energy galactic cosmic ray burst at approximately 20 GeV, which usually would not reach the Earth's surface due to terrestrial magnetism acting as a barrier. A detailed analysis was conducted. The analysis results showed that the phenomenon was the result of a fast solar wind blowing at approximately 700 km/s and generated by a solar flare, which led to the transient weakening of the Earth's magnetic shield. Disturbance in the space environment can cause trouble and failures to infrastructure on the ground, manned space flights, communication/navigation systems, and artificial satellites, etc.. In light of the influences of such trouble and failures, we believe that our research provides a valuable example demonstrating that basic cosmic ray research plays a vital role in the applied technology of space weather forecasting intended to protect cutting-edge present-day technologies.

View of cosmic ray observation system GRAPES-3 (South India)

KOJIMA Hiroshi, SHIBATA Shoichi, OSHIMA Akitoshi

KOJIMA Hiroshi, SHIBATA Shoichi, OSHIMA Akitoshi

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