業績

著書および訳書

Dietary flavonoids and their effects on osteoclast differentiation and function. Bromacology: Pharmacology of Foods and Their Components Research Signpost, 35-52., 2008

Cahallenges of nutriproteimics for　Bromacology　Bromacology: Pharmacology of Foods and Their Components Research Signpost., 171-188., 2008

学術論文、評論

Nobiletin improves hyperglycemia and insulin resistance in obese diabetic ob/ob mice. Biochem Pharmacol. in press, 2010

Phytochemicals that stimulate osteoblastic differentiation and bone formation. J Oral Biosci. 52, 2010

Honokiol inhibits osteoclast differentiation and function in vitro. Biol Pharm Bull. 33, 2010

Inhibitory effect of luteolin on osteoclast differentiation and function. Cytotechnology. 61, 2009

Magnolol enhances adipocyte differentiation and glucose uptake in 3T3-L1 cells. Life Sci. 84, 2009

　

An inhibitory effect of chrysoeriol on platelet-derived growth factor (PDGF)-induced proliferation and PDGF receptor signaling in human aortic smooth muscle cells. J Pharmacol Sci. 110, 2009

Antiresorptive microbial compounds that inhibit osteoclast differentiation, function and survival. J Pharmacol Sci. 106, 2008

Tributyltin and triphenyltin inhibit osteoclast differentiation through a retinoic acid receptor-dependent signaling pathway. Biochem Biophys Res Commun. 355, 2007

Identification of two biologically crucial hydroxyl groups of (-)-epigallocatechin gallate in osteoclast culture. Biochem Pharmacol. 73, 2007

Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Proc Natl Acad Sci U S A. 103, 2006

Curcumin inhibits the proliferation and mineralization of cultured osteoblasts. Eur J Pharmacol. 534, 2006

Inhibitory effects of mevastatin and a geranylgeranyl transferase I inhibitor on mononuclear osteoclast formation induced by RANKL or TNF-alpha. Biochem Pharmacol. 69, 2005

Cyclosporine A and FK506 induce osteoclast apoptosis in mouse bone marrow cell cultures. Bone, Vol.35, 2004

Quercetin suppresses bone resorption by inhibiting the differentiation and activaon of osteoclasts. Biol. Pharm. Bull., Vol.27, 2004

Destruxins, cyclodepsipeptides, block the formation of actin rings and prominent clear zones and ruffled borders in osteoclasts. Bone, Vol.33, 2003

Insulin-dependent adipogenesis in stromal ST2 cells derived from murine bone marrow. Biosci. Biotechnol. Biochem. Vol.67, 2003

Fenton reaction is primarily involved in a mechanism of(-)-epigallocatechin-3-gallate to induce osteoclastic cell death, Biochem. Biophys. Res. Commun. Vol.292, 2002

Compactin suppresses bone resorption by inhibiting the fusion of prefusion osteoclasts and disrupting the actin ring in osteoclasts. J. Bone Miner. Res., Vol.15, 2000

RANKL and IL-1 induce the fusion of mononuclear preosteoclasts into multinucleated osteoclasts through their receptors by activating NFκ-B. Cytotechnology, Vol.33, 2000

0steoblastic cells induce fusion and activation of osteoclasts through a mechanism independent of macrophage-colony stimulating factor production. Cell Tissue Res, Vol.298, 1999

Requirement of osteoblasts for the fusion of preosteoclasts. J. Bone Miner. Met. Vol.16, 1998

Ca²⁺-ATPase inhibitors and Ca²⁺-ionophores induce osteoclast formation in the coculture of mouse bone marrow cells and osteoblastic cells. Biochem. Biophy. Res. Comm. Vol.237, 1997

Prodigiosin 25-C and metacycloprodigiosin suppresses bone resorption by osteoclasts. Biosci. Biotech. Biochem., Vol.59, 1997

骨吸収の調節機構と骨粗鬆症治療薬, バイオサイエンスとインダストリ, Vol.56, No.11, 1998

その他

特許公開平11-246406, 骨吸収抑制剤

特許公開平11-246405, 骨吸収抑制剤

特許公開平08-092193, チオールプロテアーゼ阻害剤及び骨吸収阻害剤, ならびにペプチド誘導体

特許公開平08-081489, ポリガラクツロナーゼ阻害剤

特許公開平07-070098, 生理活性ペプチド系化合物