業績

学術論文、評論

31. H. Kasai, T. Murakami, Y. Ikuta, Y. Koseki, K. Baba, H. Oikawa, H. Nakanishi, M. Okada, M. Shoji, M. Ueda, H. Imahori, and M. Hashida. Creation of pure nanodrugs and their anticancer properties. Angew. Chem. Int. Ed. 2012, 51, 10315-10318. doi.org/10.1002/anie.201204596

30. F. Tsuji, A. Ishihara, A. Nakagawa, M. Okada, S. Kitamura, K. Kanamaru, Y. Masuda, K. Murakami, K. Irie, and Y. Sakagami. Lack of the consensus sequence necessary for tryptophan prenylation in the ComX pheromone precursor. Biosci. Biotechnol. Biochem. 2012, 76, 1492-1496. doi.org/10.1271/bbb.120206

29. F. Tsuji, A. Ishihara, K. Kurata, A. Nakagawa, M. Okada, S. Kitamura, K. Kanamaru, Y. Masuda, K. Murakami, K. Irie, and Y. Sakagami. Geranyl modification on the tryptophan residue of ComXRO-E-2 pheromone by a cell-free system. FEBS Letters 2012, 586, 174-179. doi.org/10.1016/j.febslet.2011.12.012

28. F. Tsuji, K. Kobayashi, M. Okada, H. Yamaguchi, M. Ojika and Y. Sakagami. The geranyl-modified tryptophan residue is crucial for ComXRO-E-2 pheromone biological activity. Bioorg. Med. Chem. Lett. 2011, 21, 4041-4044. doi.org/10.1016/j.bmcl.2011.04.123

27. M. Okada. Post-translational isoprenylation of tryptophan. Biosci Biotechnol Biochem. 2011, 75, 1413-1417. doi.org/10.1271/bbb.110087

26. M. Okada, F. Tsuji and Y. Sakagami. Posttranslational isoprenylation of tryptophan residues in Bacillus subtilis. The Enzymes Vol 29, Academic Press, San Diego, CA. 2011, 183-194. ISBN: 978-0-12-381339-8

25. M. Ueda, T. Tokunaga, M. Okada, Y. Nakamura, N. Takada, R. Suzuki, K Kondo. Trap-closing chemical factors of the Venus’s flytrap (Dionaea muscipulla Ellis). ChemBioChem. 2010, 11, 2378-2383. doi.org/10.1002/cbic.201000392

24. M. Okada, S. Egoshi, M. Ueda. Azido-coronatine: a useful platform for “Click chemistry”-mediated probe synthesis for bioorganic studies. Biosci. Biotechnol. Biochem. 2010, 74, 2092-2095. doi.org/10.1271/bbb.100518

23. M. Okada, S. Ito, A. Matsubara, I. Iwakura, S. Egoshi, M. Ueda. Total syntheses of coronatines by exo-selective Diels-Alder reaction and their biological activities on stomatal opening. Org. Biomol. Chem. 2009, 7, 3065-3073. doi.org/10.1039/b905159g

22. M. Okada, S. Park, T. Koshizawa, M. Ueda. (R)-Eucomic acid, a leaf-opening factor of the model organism, Lotus japonicus. Tetrahedron, 2009, 65, 2136-2141. doi.org/10.1016/j.tet.2008.11.097

21. M. Okada, J. Qi, Y. Sakagami. Chemistry of microbial signal compounds. Mycotoxins 2009, 59, 55-66. doi.org/10.2520/myco.59.55

20. H. Sugahara, T. Kondo, M. Okada, Y. Ikeda, K. Kaida, R. Fudou, T. Mizuno, Y. Sakagami. Articulospora sp. produces Art1, an inhibitor of bacterial histidine kinase. Biosci. Biotechnol. Biochem. 2008, 72, 2521-2525. doi.org/10.1271/bbb.80021

19. M. Okada, A. Matsubara, M. Ueda. Synthesis of photoaffinity probe based on the leaf-opening factor from genus Albizzia. Tetrahedron Lett. 2008, 49, 3794-3796. doi.org/10.1016/j.tetlet.2008.04.002

18. 上田 実, 中村葉子, 岡田正弘. 植物の就眠運動と食虫植物の補虫運動に関する生物有機化学. 植物の生長調節, 2008, 43, 61-71.

17. M. Okada, H. Yamaguchi, I. Sato, F. Tsuji, D. Dubnau, Y. Sakagami. Chemical structure of posttranslational modification with a farnesyl group on tryptophan. Biosci. Biotechnol. Biochem. 2008, 72, 914-918. doi.org/10.1271/bbb.80006

16. M. Okada, H. Yamaguchi, I. Sato, F. Tsuji, J. Qi, D. Dubnau, Y. Sakagami. Acid labile ComX pheromone from Bacillus mojavensis RO-H-1. Biosci. Biotechnol. Biochem., 2007 71, 1807-1810. doi.org/10.1271/bbb.70245

15. M. Ueda, Y. Nakamura, M. Okada. Endogenous factors involved in the regulation of movement and “memory” in plants. Pure Appl. Chem. 2007, 79, 513-521. doi.org/10.1351/pac200779040519

14. 岡田正弘, 坂神洋次. 生物の密度と化学因子. 蛋白質・核酸・酵素「ケミカルバイオロジー」, 2007, 52, 1673-1678.

13. 上田 実, 中村葉子, 岡田正弘. 植物のリズム運動を制御する生理活性天然物のケミカルバイオロジー. 蛋白質・核酸・酵素「ケミカルバイオロジー」, 2007, 52, 1667-1672.

12. M. Okada, H. Yamaguchi, I. Sato, S.J. Cho, D. Dubnau, Y. Sakagami. Structure–activity relationship studies on quorum sensing ComXRO-E-2 pheromone. Bioorg. Med. Chem. Lett. 2007, 17, 1705-1707. doi.org/10.1016/j.bmcl.2006.12.070

11. 上田 実, 中村葉子, 岡田正弘. 植物の外部シグナルセンシング：就眠運動と刺激の記憶. "感覚センサー：生物の感覚機能の驚くべき多様性にせまる、そして応用へ". 細胞工学, 2007, 26, 898-902.

10. 上田 実, 中村葉子, 真鍋良幸, 岡田正弘. 就眠運動の化学メカニズム. 遺伝, 2007, 61, 28-29.

9. 岡田正弘, 坂神洋次. ComXフェロモン構造決定における構造推定体およびComXフェロモンの合成. 有機合成化学協会誌, 2007, 65, 608-617. doi.org/10.5059/yukigoseikyokaishi.65.608

8. 岡田正弘. 12個のアミノ酸が植物の形を制御する？！. 月刊化学 2007, 62, 63.

7. 岡田正弘. たった１つの3-ヒドロキシプロリンの欠如で骨形成不全症に！？. ファルマシア 2007, 43, 919-920.

6. Y. Nakamura, A. Matsubara, M. Okada, T. Kumagai, M. Ueda. Double fluorescence-labeling study on genus Albizzia using a set of fluorecence-labeled leaf-movement factors to identify the spatial distribution of their receptors. Chem. Lett. 2006, 35, 744-745. doi.org/10.1246/cl.2006.744

5. M. Okada, I. Sato, S.J. Cho, D. Dubnau Y. Sakagami. Chemical synthesis of ComX pheromone and related peptides containing isoprenoidal tryptophan residue. Tetrahedron 2006, 62, 8907-8918. doi.org/10.1016/j.tet.2006.06.074

4. 岡田正弘, 坂神洋次. 枯草菌のComXフェロモンに見られる新規翻訳後修飾. 化学と生物, 2006, 44, 356-357.

3. M. Okada, I. Sato, S.J. Cho, H. Iwata, T. Nishio, D. Dubnau, Youji Sakagami. Structure of the Bacillus subtilis quorum-sensing peptide pheromone ComX. Nature Chemical Biology 2005, 1, 23-24. doi.org/10.1038/nchembio709

2. T. Ohashi, Y. Ito, M. Okada, Y. Sakagami. Isolation and stomatal opening activity of two oxylipins from Ipomoea tricolor. Bioorg. Med. Chem. Lett. 2005, 15, 263-265. doi.org/10.1016/j.bmcl.2004.10.088

1. M. Okada, I. Sato, S.J. Cho, Y. Suzuki, M. Ojika, D. Dubnau, Y. Sakagami. Towards structural determination of the ComX pheromone: synthetic studies on peptides containing geranyltryptophan. Biosci. Biotechnol. Biochem. 2004, 68, 2374-2387. doi.org/10.1271/bbb.68.2374

受賞

農芸化学奨励賞 （2010年）　　　　　　　

農芸化学会東北支部奨励賞 （2009年）

第51回天然有機化合物討論会奨励賞（2009年, ポスターの部）

第7回天然物化学談話会奨励賞（2007年）

第47回天然有機化合物討論会奨励賞（2005年, 口頭発表の部）