Hagiwara, S., Nishida, N., Ida, H., Ueshima, K., Minami, Y., Takita, M., Aoki, T., Morita, M., Chishina, H., Komeda, Y., Yoshida, A., Park, AM., Sato, M., Kawada, A., Nakano, H., Nakagawa, H., and Kudo, M. (2022) Role of phlebotomy in the treatment of liver damage related to erythropoietic porphyria. Sci Rep,12, 6100.
2021年
Hara, S., Kusunoki, T., Nakagawa, H., Toyoda, Y., Nojiri, S., Kamiya, K., Furukawa, M., Takata, Y., Okada, H., Anzai, T., Matsumoto, F., and Ikeda, K. Association between earwax-determinant genotypes and acquired middle ear cholesteatoma in a Japanese population. Otolaryngol Head Neck Surg, 166, 139-145.
2019年
Inoue, Y., Morita, T., Onozuka, M., Nakagawa, H., Sano, M., Saito, K., Kondo, M., Yoshida, H., Kishino, T., and Ikegami, Y. (2019) Impact of Q141K on the transport of epidermal growth factor receptor tyrosine kinase inhibitors by ABCG2. Cells, 8, E763.
Ishiguro, J., Ito, H., Tsukamoto, M., Iwata, H., Nakagawa, H., and Matsuo, K. (2019) A functional single nucleotide polymorphism in ABCC11, rs17822931, is associated with the risk of breast cancer in Japanese. Carcinogenesis, 40, 537-543.
Yoshida, M., Adachi, K., Murase, H., Nakagawa, H., and Doi, T. (2019) Parallel Synthesis and Biological Evaluation of Destruxin E Analogs Modified with a Side Chain in the α-Hydroxycarboxylic Acid Moiety. European J Org Chem., 7, 1669-1676.
Tsukamoto, M., Yamashita, M., Nishi, T., and Nakagawa, H. (2019) A human ABC transporter ABCC4 gene SNP (rs11568658, 559 G>T, G187W) reduces ABCC4-dependent drug resistance. Cells, 8, E39.
2018年
Kusunoki, T., Nakagawa, H., Tsukamoto, M., Toyoda, Y., Kamiya, K., Okada, H., Hara, S., Furukawa, M. and Ikeda, K. (2018) Possible Association between Middle Ear Cholesteatoma and A Single Nucleotide Polymorphism 538G>A in ABCC11, A Human Earwax Type Determinant., J. Mol. Genet. Med., 12, 362-364.
Mitani, Y., Satake, K., Tsukamoto, M., Nakamura, I., Kadioglu, O., Teruya, T., Yonezawa, T., Cha, BY., Efferth, T., Woo, JT., and Nakagawa, H. (2018) Epimagnolin A, a tetrahydrofurofuranoid lignan from Magnolia fargesii, reverses ABCB1-mediated drug resistance. Phytomedicine, 51, 112-119.
Efferth, T., Banerjee, M., Abu-Darwish, MS., Abdelfatah, S., Böckers, M., Bhakta-Guha, D., Bolzani, V., Daak, S., Demirezer, ÖL., Dawood, M., Efferth, M., El-Seedi, HR., Fischer, N., Greten, HJ., Hamdoun, S., Hong, C., Horneber, M., Kadioglu, O., Khalid, HE., Khalid, SA., Kuete, V., Mahmoud, N., Marin, J., Mbaveng, A., Midiwo, J., Nakagawa, H., Naß, J., Ngassapa, O., Ochwang'I, D., Omosa, LK., Ooko, EA., Özenver, N., Poornima, P., Romero, MR., Saeed, MEM., Salgueiro, L., Seo, EJ., Yan, G., Yasin, Z., Saeed, EM., and Paul, NW. (2018) Biopiracy versus One-World Medicine-From colonial relicts to global collaborative concepts. Phytomedicine, 11, 30190-30199.
Nakagawa, H., Toyoda, Y., Albrecht, T., Tsukamoto, M., Praetorius, M. Ishikawa, T., Kamiya, K., Kusunoki, T., Ikeda, K., and Sertel, S. (2018). Are human ATP-binding cassette transporter C11 and earwax associated with the incidence of cholesteatoma? Med. Hypotheses. 114, 19-22.
2017年
Kusunoki, T., Nakagawa, H., Tsukamoto, M., Toyoda, Y., Kamiya, K., Okada, H., Hara, S., Hatakeyama, K., Furukawa, M., Ikeda, K. (2017). Earwax Phenotype Related to A Risk Factor of Middle Ear Cholesteatoma. M. J. Othol. 1, 003.
Tsukamoto, M., Sato, S., Satake, K., Miyake, M., and Nakagawa, H.. Quantitative evaluation of drug resistance profile of cells expressing wild-type or genetic polymorphic variants of the human ABC transporter ABCC4. Int. Journal of Molecular Sciences. 18, E1435.
Toyoda, Y., Takada, T., Gomi, T., Nakagawa, H., Ishikawa, T., and Suzuki, H. (2017). Clinical and Molecular Evidence of ABCC11 Protein Expression in Axillary Apocrine Glands of Patients with Axillary Osmidrosis. Int. Journal of Molecular Sciences. 18, E417.
2016年
Yoshida, M., Sato, H., Murase, H., Nakagawa, H., and Doi, T. (2016). Combinatorial Solid-Phase Synthesis and Biological Evaluation of Cyclodepsipeptide Destruxin B as a Negative Regulator for Osteoclast Morphology. ACS Combinatorial Science. 18, 590-5.
Effert, T., Banerjee, M., Paul, NW., Abdelfatah, S., Arend, J., Elhassan, G., Hamdoun, S., Hamm, R., Hong, C., Kadioglu, O., Naß, J., Ochwangi, D., Ooko, E., Ozenver, N., Saeed, M.E.M., Schneider, M., Seo, EJ., Wu, CF., Yan, G., Zeino, M., Zhao, Q., Abu-Darwish, M.S., Andersch, K., Alexie, G., Bessarab, D., Bhakta-Guha, D., Bolzani, V., Dapat, E., Donenko, F.V., Efferth, M., Greten, HJ., Gunatilaka, L., Hussein, AA., Karadeniz, A., Khalid, HE., Kuete, V., Lee, IS., Liu, L., Midiwo, J., Mora, R.,Nakagawa, H., Ngassapa, O., Noysang, C., Omosa, LK., Roland, FH., Shahat, AA., Saab, A., Saeed, EM., Shan, L., Titinchi, S.J.J. (2016). Biopiracy of natural products and good bioprospecting practice. Phytomedicine, 23, 166-73.
Toyoda, Y., Gomi, T., Nakagawa, H., Nagakura, M., and Ishikawa, T. (2016). Diagnosis of human axillary osmidrosis by genotyping of the human ABCC11 gene: Clinical practice and basic scientific evidence. Biomed Res Int., 7670483.
Fukunaga,K., Nakagawa, H., Ishikawa, T., Kubo, M., and Mushiroda, T. (2016). ABCB1 polymorphism is associated with atorvastatin-induced liver injury in Japanese population. BMC Genetics, 17, 79.
2015年
Satake, K., Tsukamoto, M., Mitani, Y., Regasini LO, Bolzani Vda S, Efferth, T., and Nakagawa, H. (2015). Human ABCB1 confers cells resistance to cytotoxic guanidine alkaloids from Pterogyne nitens. Biomed Mater Eng. 249-256.
Tajima, Y., Murase, H., Satake, K., Mitani, Y., Regasini LO, Bolzani Vda S, Efferth, T., and Nakagawa, H.(2015). Nitensidine A, a guanidine alkaloid from Pterogyne nitens, induces osteoclastic cell death. Cytotechnology. 585-592.
Doi, T., Yamaguchi, N., Ohsawa, K., Nakai, K., Yoshida, M., Satake, K., Mitani, Y., Nakagawa, H., Takahashi, T., and Ishikawa, T. (2015). Synthesis and Biological Evaluation of C-Aromataxane Derivatives as P-Glycoprotein-Mediated Multi Drug Resistance Reversal Agents. Heterocycles, 90, 482-501.
2014年
Yoshida, M., Sato, H., Ishida, Y., Nakagawa, H., and Doi, T. (2014). Scalable Solution-Phase Synthesis of Biologically Active Cyclodepsipeptide Destruxin E, a Potent Negative Regulator of Osteoclast Morphology. J. Org. Chem., 296-306.
Satake, K., Toyoda, Y., and Nakagawa, H.(2014). Drugs affecting epigenetics of ABC transporters for drug resistance. Thomas E., editor. Resistance to Targeted ABC Transporters in Cancer, Resistance to Targeted Anti-Cancer Therapeutics Vol. 4, Springer International Publishing Switzerland, 273-297.
Tajima, Y., Nakagawa, H., Tamura, A., Kadioglu, O., Satake, K., Mitani, Y., Murase, H., Regasini LO, Bolzani Vda S, Ishikawa, T., Fricker, G., and Efferth, T. (2014). Nitensidine A, a guanidine alkaloid from Pterogyne nitens, is a novel substrate for human ABC transporter ABCB1. Phytomedicine, 323-332.Tajima, Y. and Nakagawa, H. contributed equally to this work.
2013年
Inoue, Y., Ikegami, Y., Sano, K., Suzuki, T., Yoshida, H., Nakamura, Y., Nakagawa, H., and Ishikawa, T. Gefitinb Enhances the Antitumor Activity of CPT-11 in vitro and in vivo by Inhibiting ABCG2 but not ABCB1: A New Clue to Circumvent Gastrointestinal Toxicity Risk. Chemotherapy, 260-272.
Ishikawa, T., Wakabayashi-Nakao, K., and Nakagawa, H.(2013). Methods to Examine the Impact of Nonsynonymous SNPs on Protein Degradation and Function of Human ABC Transporter. Methods Mol. Biol., 225-250.
Ishikawa, T., Kajimoto, Y., Sun, W., Nakagawa, H., Inoue, Y., Ikegami, Y., Miyatake, S., and Kuroiwa, T. (2013). Role of Nrf2 in Cancer Photodynamic Therapy: Regulation of Human ABC Transporter ABCG2. J. Pharm. Sci., 3058-3069.
Nakagawa, H., Toyoda, Y., Wakabayashi-Nakao, K., Tamaki, H., Osumi, M., and Ishikawa, T. （2011）. Ubiquitin-mediated proteasomal degradation of ABC transporters: A new aspect of genetic polymorphisms and clinical impacts. J. Pharm. Sci., 100, 3602-3619.
Ishikawa, T., Nakagawa, H., Hagiya, Y., Nonoguchi, N., Miyatake, S., and Kuroiwa, T. （2010）. Key Role of Human ABC Transporter ABCG2 in Photodynamic Therapy and Photodynamic Diagnosis. Advances in Pharmacological Science, in press.
Wakabayashi-Nakao, K., Tamura, A., Toyoda, Y., Koshiba, S., Nakagawa, H., and Ishikawa, T. （2010）. Production of cells with targeted integration of gene variants of human ABC transporter for stable and regulated expression using the Flp recombinase system. Methods Mol. Biol., 648, 139-159.
2009年
Furukawa, T., Wakabayashi, K., Tamura, A., Nakagawa, H., Morishima, Y., Osawa, Y., and Ishikawa, T. （2009）. Major SNP （Q141K） Variant of Human ABC Transporter ABCG2 Undergoes Lysosomal and Proteasomal Degradations. Pharm. Res., 26, 469-479.
Wakabayashi-Nakao, K., Tamura, A., Furukawa, T., Nakagawa, H., and Ishikawa, T. （2009）. Quality control of human ABCG2 protein in the endoplasmic reticulum: Ubiquitination and proteasomal degradation. Advanced Drug Delivery Reviews, 61, 66-72.
Toyoda, Y., Sakurai, A., Mitani, Y., Nakashima, M., Yoshiura, K., Nakagawa, H., Sakai, Y., Lezhava, A., Hayashizaki, Y., Niikawa, N., and Ishikawa, T. （2009）. Earwax, osmidrosis, and breast cancer: Why does one SNP （538G>A） in the human ABC transporter ABCC11 gene determine earwax type? FASEB J., 23, 2001-2013.
Adachi, T., Nakagawa, H., Hagiya, Y., Yasuoka, T., and Ishikawa, T. （2009）. Transport-metabolism interplay: LXRa-mediated induction of human ABC transporter ABCC2 （cMOAT/MRP2） in HepG2 cells. Mol. Pharmaceutics., 6, 1678-1688.
Ishikawa, T. and Nakagawa, H.（2009）. Human ABC Transporter ABCG2 in Cancer Chemotherapy and Pharmacogenomics. J. Exp. Ther. Oncol., 8, 5-24.
Nakagawa, H., Wakabayashi-Nakao, K., Tamura, A., Koshiba, S., Toyoda, Y., and Ishikawa, T. （2009）. Disruption of N-linked glycosylation enhances ubiquitin-mediated proteasomal degradation of human ATP-binding cassette transporter ABCG2. FEBS J., 276, 7237-7252. Selected for the Virtual Issue on Glycosylation.
萩谷祐一郎, 足立達彦, 小倉俊一郎, 安然, 田村藍, 中川大, 望月徹, 石川智久. （2009）. ポルフィリンの光励起によるヒトABCトランスポーターABCG2とヘムオキシゲナーゼの誘導におけるNrf2の役割. Porphyrins, The Society for Porphyrin Research, 18, 13-17.
Nakagawa, H., Tamura, A., Wakabayashi, K., Hoshijima, K., Komada, M., Yoshida, T., Kometani, S., Matsubara, T., Mikuriya, K., and Ishikawa, T. （2008）. Ubiquitin-mediated proteasomal degradation of non-synonymous SNP Variants. Biochemical J., 411, 623-631.
Hagiya, Y., Adachi, T., Ogura, S., An, R., Tamura, A., Nakagawa, H., Okura, I., Mochizuki, T., and Ishikawa, T. （2008）. Nrf2-dependent Induction of Human ABC Transporter ABCG2 and Hemeoxygenase-1 in HepG2 cells by Photoactivation of Porphyrins: Biochemical Implications for Cancer Cell Response to Photodynamic Therapy. J. Exp. Ther. Oncol., 7, 153-167.
2007年
Nakagawa, H., Hasumi, K., Takami, M., Aida-Hyugaji, S., Woo, JT., Nagai, K., Ishikawa, T., and Wachi, M. （2007）. Identification of two biologically-crucial hydroxyl groups of （–）-epigallocatechin gallate in osteoclast culture. Biochem. Pharmacol., 73, 34-43.
Adachi, T., Nakagawa, H., Chung, I., Hagiya, Y., Hoshijima, K., Noguchi, N., Kuo, T.M., and Ishikawa, T. （2007）. Nrf2-dependent and -independent Induction of ABC Transporters ABCC1, ABCC2, and ABCG2 in HepG2 Cells under Oxidative Stress. J. Exp. Ther. Oncol., 6, 335-348. Adachi, T. and Nakagawa, H. contributed equally to this work.
Wakabayashi, K., Nakagawa, H., Tamura, A., Koshiba, S., Hoshijima, K., Komada, M., and Ishikawa, T. （2007）. Intramolecular disulfide bond is a critical checkpoint determining degradative fates of ABC transporter ABCG2 protein.J. Biol. Chem., 282, 27841-27846.
Aida-Hyugaji, S.,Nakagawa, H., Nomura, J., Sakurai, M., Nagashima, U., and Ishikawa, T. （2007）. Theoretical Studies for Molecular Modeling of New Camptothecin Analogues. Croat. Chemica. Acta, 80, 277-281.
Saito, H., Hirano, H., Nakagawa, H., Hoshijima, K., and Ishikawa, T. （2007）. Transport Mechanism-Based Drug Molecular Design: A New Strategy of High-Speed Screening and Quantitative SAR Analysis of ABC Transport ABCG2 to design Novel Anticancer Drugs. Progress in Cancer Drug Resistance Research, Nova Publishers, 43-71.
2006年
Wakabayashi, K., Nakagawa, H., Adachi, T., Kii, I., Kobatake, E., Kudo, A., and Ishikawa, T. （2006）. Cysteine-603 is a critical amino acid for homodimer formation of human ATP-binding cassette transporter ABCG2: a new approach using the flp recombinase system. J. Exp. Ther. Oncol., 5, 205-222.
Ishikawa, T., Ikegami, Y., Sano, K., Nakagawa, H., and Sawada, S. （2006）. Transport mechanism-based drug molecular design: novel camptothecin analogues to circumvent ABCG2-associated drug resistance of human tumor cells. Curr.Pharm. Des., 12, 313-325.
Nakagawa, H., Saito, H., Ikegami, Y., Aida-Hyugaji, S., Sawada, S., and Ishikawa, T. （2006）. Molecular Modeling of New Camptothecin Analogues to Circumvent ABCG2-mediated Drug Resistance in Cancer. Cancer Lett., 234, 81-89.
Woo, JT., Kawatani, M., Kato, M., Shinki, T., Yonezawa, T., Kanoh, N., Nakagawa, H., Takami, M., Lee, K.H., Stern, P.H., Nagai, K., and Osada, H. （2006）. Reveromycin A, a novel agent for osteoporosis inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Proc. Natl. Acad. Sci. USA., 103, 4729-4734.
Saito, H., Hirano, H., Nakagawa, H., Fukami, T., Oosumi, K., Murakami, K., Kimura, H., Kouchi, T., Konomi, M., Tao, E., Tsujikawa, N., Tarui, S., Nagakura, M., Osumi, M., and Ishikawa, T. （2006）. A New Strategy of High-Speed Screening and Quantitative SAR Analysis To Evaluate Human ABC Transporter ABCG2-Drug Interactions. J. Pharmacol. Exp. Ther., 317, 1114-1124.
Hirano, H., Kurata, A., Onishi, Y., Sakurai, A., Saito, H., Nakagawa, H., Nagakura, M., Tarui, S., Kanamori, Y., Kitajima, M., and Ishikawa, T. （2006）. High-Speed Screening and QSAR Analysis of Human ATP-Binding Cassette Transporter ABCB11 （Bile Salt Export Pump） To Predict Drug-induced Intrahepatic Cholestasis. Mol. Pharmaceutics, 3, 252-265.
Tamura, A., Watanabe, M., Saito, H., Nakagawa, H., Kamachi, T., Okura, I., and Ishikawa, T. （2006）. Functional Validation of The Genetic Polymorphisms of Human ABC Transporter ABCG2: Identification of Alleles That Are Defective in Porphyrin Transport. Mol. Pharmacol., 70, 287-296.
Tamura, A., Wakabayashi, K., Onishi, Y., Nakagawa, H., Tsuji, M., Matsuda, Y., and Ishikawa, T. （2006）. Genetic Polymorphisms of Human ABC Transporter ABCG2: Development of the Standard Method for Functional Validation of SNPs by using the Flp Recombinase System. J. Exp. Ther. Oncol., 6, 1-11.
Shirasaka, Y., Onishi, Y., Sakurai, A., Nakagawa, H., Ishikawa, T., and Yamashita, S. （2006）. Evaluation of Human P-Glycoprotein （MDR1/ABCB1） ATPase Activity Assay Method by Comparing with in Vitro Transport Measurements: Michaelis-Menten Kinetic Analysis to Estimate the Affinity of P-Glycoprotein to Drugs. Biol. Pharm. Bull., 29, 2465-2471.
Ishikawa, T., Nakagawa, H., and Kuo, T.M. （2006）. The GS-X Pumps/Multidrug Resistance Proteins （MRP） Role of Glutathione in Their Function and Gene Regulation. In: Aiello, Christopher V., editor. Multidrug Resistance-associated Proteins. Multidrug resistance-associated proteins, Nova Publishers, 1-29.
田村藍, 大西裕子, 渡邉正人, 齊藤光, 中川大, 蒲池利章, 大倉一郎, 石川智久. （2006）. ヒトABCトランスポーターABCG2の遺伝子多型とポルフィリン症のリスク. Porphyrins, The Society for Porphyrin Research, 15, 21-22.
Woo, JT., Nakagawa, H., Krecic, K.M., Nagai, K., Hamilton, A.D., Sebti, S.M., and Stern, P.H. （2005）. Inhibitory effects of mevastatin and a geranylgeranyl transferase I inhibitor （GGTI-2166） on mononuclear osteoclast formation induced by receptor activator of NFkappaB ligand （RANKL） or tumor necrosis factor-alpha （TNF-α）. Biochem. Pharmacol., 69, 87-95.
Takahashi, T., Nakai, K., Doi, T., Yasunaga, M., Nakagawa, H., and Ishikawa, T. （2005）. Synthesis and Evaluation of 3D Templates Based on a Taxane Skeleton to Circumvent P-glycoprotein-associated Multidrug Resistance of Cancer. Bioorg. Med. Chem. Lett., 15, 2601-2605.
Ishikawa, T., Tamura, A., Saito, H., Wakabayashi, K., and Nakagawa, H.（2005）. Pharmacogenomics of the Human ABC Transporter ABCG2: From Functional Evaluation to Drug Molecular Design. Naturwissenschaften,92, 1-13.
Woo, JT., Nakagawa, H., Notoya, M., Yonezawa, T., Udagawa, N., Lee, IS., Ohnishi, M., Hagiwara. H., andNagai, K. （2004）. Quercetin suppresses bone resorption by inhibiting differentiation and activation of osteoclasts. Biological Pharm. Bull., 27, 504-509.
Nakagawa, H., Hasumi, K., Woo, JT., Nagai, K., and Wachi, M. （2004）. Generation of hydrogen peroxide primarily contributes to the induction of Fe（II）-dependent apoptosis in Jurkat cells by （–）-epigallocatechin gallate. Carcinogenesis, 25, 1567-1574.
2003年
Nakagawa, H., Takami, M., Udagawa, N., Sawae, Y., Suda, K., Sasaki, T., Takahashi, N., Wachi, M., Nagai, K., and Woo, JT. （2003）. Destruxins, cyclodepsipeptides, block the formation of actin rings, and prominent clear zones and ruffled borders in osteoclasts. Bone, 33, 443-455.
2002年
Nakagawa, H., Wachi, M., Woo, JT., Kato, M., Kasai, S., Takahashi, F., Lee, IS., and Nagai, K. （2002）. Fenton reaction is primarily involved in a mechanism of （-）-epigallocatechin-3-gallate to induce osteoclastic cell death. Biochem. Biophys. Res. Commun., 292, 94-101.
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