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村松 渉 (Wataru Muramatsu)

 


 

研究テーマ

効率的なペプチド合成を指向した新規触媒反応の開発

略歴

平成15年3月
京都薬科大学薬学部生物薬学科 卒業
平成17年3月
京都薬科大学大学院薬学研究科生物薬科学専攻修士課程 修了  
平成20年3月
京都大学大学院薬学研究科創薬科学専攻博士後期課程 修了
 

職歴

平成20年4月
マサチューセッツ工科大学
上原記念生命科学財団海外留学助成金ポストドクトラルフェロー(Gregory C. Fu教授)
平成22年2月             長崎大学大学院医歯薬学総合研究科テニュアトラック助教

平成28年10月            中部大学分子性触媒研究センター 特任助教(山本尚教授)

平成30年4月                    中部大学分子性触媒研究センター 助教(山本尚教授)

令和2年4月                     中部大学分子性触媒研究センター 特任准教授(山本尚教授)


受賞歴

平成19年 12月
京大化研学生研究賞
平成20年  3月
上原記念生命科学財団海外留学助成金ポストドクトラルフェローシップ

Objective

Development of Novel Catalytic Method for the Synthesis of Peptides

Degree

2003
B.Pharm.Sc., Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University
2005
M.Pharm.Sc., Graduate School of Pharmaceutical Sciences, Kyoto Pharmaceutical University
2008                               D.Pharm.Sc., Graduate School of Pharmaceutical Sciences, Kyoto University

Experience

2008-2010                       Uehara Memorial Foundation Postdoctoral Fellow
Department of Chemistry, Massachusetts Institute of Technology, USA
Supervisor: Professor Gregory C. Fu
2010-2015                      Assistant Professor
                                     Graduate School of Biomedical Sciences, Nagasaki University, Japan

2016-2018                       Research Assistant Professor
                                     Molecular Catalyst Research Center, Chubu University, Japan
                                     Supervisor: Professor Hisashi Yamamoto

2018-2020                       Assistant Professor
                                     Supervisor: Professor Hisashi Yamamoto
                                     Molecular Catalyst Research Center, Chubu University, Japan

2020-                             Associate Professor
                                     Supervisor: Professor Hisashi Yamamoto
                                     Molecular Catalyst Research Center, Chubu University, Japan

List of Publications

  1. Stereoselective Synthesis of C3-C12 Dihydropyran Portion of Antitumor Laulimalide Using Copper-Catalyzed Oxonium Ylide Formation-[2,3] Shift, T. Yakura, W. Muramatsu, J. Uenishi, Chem. Pharm. Bull. 2005, 53, 989-994.

  2. Regioselective Acylation of 6-O-Protected Octyl β-D-Glucopyranoside by DMAP Catalysis, W. Muramatsu, T. Kawabata, Tetrahedron Lett. 2007, 48, 5031-5033.

  3. A Catalytic One-Step Process for the Chemo- and Regioselective Acylation of Monosaccharides, T. Kawabata, W. Muramatsu, T. Nishio, T. Shibata, H. Schedel, J. Am. Chem. Soc. 2007, 129, 12890-12895 (Highlighted in Synfacts 2007, 1314).

  4. Regioselective Acylation of Octyl β-D-Glucopyranoside by Chiral 4-Pyrrolidinopyridine Analogues, T. Kawabata, W. Muramatsu, T. Nishio, T. Shibata, Y. Uruno, R. Stragies, Synthesis 2008, 747-753.

  5. Functional Group Tolerance in Organocatalytic Regioselective Acylation of Carbohydrates, Y. Ueda, W. Muramatsu, K. Mishiro, T. Furuta, T. Kawabata, J. Org. Chem. 2009, 74, 8802-8805.

  6. Perfect Regioselective and Sequential Protection of Glucopyranosides, W. Muramatsu, K. Mishiro, Y. Ueda, T. Furuta, T. Kawabata, Eur. J. Org. Chem. 2010, 2010, 827-831.

  7. Selective Monobenzoylation of 1,2- and 1,3-Diols Catalyzed by Me2SnCl2 in Water (Organic Solvent Free) under Mild Conditions, W. Muramatsu, J. M. William, O. Onomura, J. Org. Chem. 2011, 77, 754-759.

  8. 最近の研究に観る非酵素触媒を用いた速度論的分割, 村松渉,有機合成化学協会誌 2011, 69, 1044-1045

  9. Organotin-Catalyzed Highly Regioselective Thiocarbonylation of Nonprotected Carbohydrates and Synthesis of Deoxy Carbohydrates in a Minimum Number of Steps, W. Muramatsu, S. Tanigawa, Y. Takemoto, H. Yoshimatsu, O. Onomura, Chem. Eur. J. 2012, 18, 4850-4853.

  10. Chemo- and Regioselective Monosulfonylation of Nonprotected Carbohydrates Catalyzed by Organotin Dichloride under Mild Conditions, W. Muramatsu, J. Org. Chem. 2012, 77, 8083-8091.

  11. 有機金属試薬を用いるケトンおよびケチミン類の化学選択的合成, 村松渉,ファルマシア 2012, 48, 1185.

  12. Selectivity Switch in the Catalytic Functionalization of Nonprotected Carbohydrates: Selective Synthesis in the Presence of Anomeric and Structurally Similar Carbohydrates under Mild Conditions, W. Muramatsu, Y. Takemoto, J. Org. Chem. 2013, 78, 2336-2345.

  13. Simple and Direct sp3 C-H Bond Arylation of Tetrahydroisoquinolines and Isochromans via 2,3-Dichloro-5,6-Dicyano-1,4-Benzoquinoline Oxidation under Mild Conditions, W. Muramatsu, K. Nakano, C.-J. Li, Org. Lett. 2013, 15, 3650-3653.

  14. Regio- and Stereoselective Controlled Koenigs-Knorr-Type Monoglycosylation of Secondary Hydroxy Groups in Carbohydrates Utilizing the High Site Recognition Ability of Organotin Catalysts, W. Muramatsu, H. Yoshimatsu, Adv. Synth. Catal. 2013, 355, 2518-2524.

  15. Direct sp3 C-H Bond Arylation, Alkylation, and Amidation of Tetrahydroisoquinolines Mediated by Hypervalent Iodine(III) under Mild Conditions, W. Muramatsu, K. Nakano, C.-J. Li, Org. Biomol. Chem. 2014, 12, 2189-2192.

  16. Organocatalytic Approach for C(sp3)-H Bond Arylation, Alkylation, and Amidation of Isochromans under Facile Conditions, W. Muramatsu, K. Nakano, Org. Lett. 2014, 16, 2042-2045

  17. Catalytic and Regioselective Oxidation of Carbohydrates to Synthesize Keto-Sugars under Mild Conditions, W. Muramatsu, Org. Lett. 2014, 16, 4846-4849.

  18. Hypervalent Iodine(III)-Mediated C(sp3)-H Bond Arylation, Alkylation, and Amidation of Isothiochroman, W. Muramatsu, K. Nakano, Tetrahedron Lett. 2015, 56, 437-440.

  19. Efficient C(sp3)-H Bond Functionalization of Isochroman by AZADOL Catalysis, W. Muramatsu, K. Nakano, Org. Lett. 2015, 17, 1549-1552.

  20. Recent Advances in the Regioselective Functionalization of Carbohydrates Using Non-Enzymatic Catalysts, W. Muramatsu,Trends Glycosci. Glycotech. 2016, 28, E1-E11.

  21. 非酵素触媒を用いる糖類の位置選択的官能基化に関する最近の動向, 村松渉,Trends Glycosci. Glycotech. 2016, 28, J1-J11.

List of Proceedings

  1. Direct Aldol-Reduction Process Using Difluoromethyl Aryl Ketones and Aryl Aldehydes in the Presence of Potassium tert-Butoxide: One-Pot Efficient Stereoselective Synthesis of Symmetrical and Unsymmetrical anti-2,2-Difluoropropane-1,3-Diols, M. Médebielle, M.-H. Bellance, W. Xu, W. R. Dolbier Jr., W. Muramatsu, Abstract of Paper, 242th ACS National Meeting & Exposition 2011, 242, FLUO-34.

  2. Chemo- and Regioselective Functionalization of Non-protected Carbohydrates under Practical Conditions, W. Muramatsu, Yuki Takemoto, Abstract of Paper, 245th ACS National Meeting & Exposition 2013, 245, ORGN-549.

 

List of Patents

  1. ヒドロキシエステル誘導体の製造方法, 特許第5645537.

  2. β-グルコピラノシドチオカルボニルエステル化合物の製造方法, 特許第5669618.

  3. α-ピラノシドチオカルボニルエステル化合物の製造方法, 特許第5669637.

  4. ピラノシドチオカルボニルエステル化合物の製造方法, 特許第5669643.

Invited Presentations

  1. A Catalytic One-Step Process for the Chemo- and Regioselective Acylation of Monosaccharides, ICR Award Lecture in the 107th ICR Annual Symposium, Kyoto University, Japan, 2007.

  2. Selective Functionalization of Non-Protected Polyols Catalyzed by Organo- and Organometal Catalysis, Hong Kong University of Science and Technology, Hong Kong, 2011.

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