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山本 尚(Hisashi Yamamoto)

山本 尚教授

分子性触媒研究センター長

総合工学研究所長

教授

研究概要と履歴

最善、最適の触媒を創出することは、有機化学者に課せられた最重要課題である。小さなプロトン(水素カチオン)は、無害で、有効な触媒であるが、その触媒反応を思い通りに制御することは難しい。酵素は見事にプロトンを使いこなしているが、同じことをフラスコ内で再現することはできない。私たちはプロトンに替わる触媒を探索し、いち早く1980年代初頭にC2型キラル・ルイス酸触媒が巨大分子量の酵素分子の機能を真似ながらも、その仕組みを単純化した C2対称軸を持つキラル・ルイス酸触媒を提案・実現した。この触媒は優れた不斉合成の機能を発現し、その後続々と内外から発表された同様の不斉分子性酸触媒の源流となった。本概念はその信頼性と有用性から、現在では不斉炭素-炭素結合を作る有機合成に必須の手法として広く定着している。すなわち、我々は、キラル・ルイス酸触媒の研究を世界に先駆けて提案、その有用性を実証し、不斉炭素骨格生成に有効な「分子性酸触媒」という新分野を拓いた。

最近では、さらに高選択性を得ることのできる、ルイス酸とブレンステッド酸を組み合わせた複合型酸触媒、ルイス酸の金属中心がキラルとなるシス・ベータ型金属触媒、2つの螺旋を組み合わせたシス・アルファ型鉄触媒の創成に成功している。これらの触媒は炭素—炭素結合の不斉合成に留まらず、酸素-炭素、窒素-炭素等を含む、第二世代の分子性酸触媒の創成に繋がっている。さらに、上記の概念を用いる不斉酸化反応を数々提案し、その有効性も同時に実証した。一方では、金属に替わる毒性のまったくない強力なスーパー・ブレンステッド酸触媒を開発、それを駆使した3次元分子の1工程合成に成功し、多くの労力と、莫大なエネルギー・資源を消費する従来型多段階の化学合成から脱却、クリーンで省資源型のカスケード型合成法に成功した。

開発した触媒や反応剤は工業的にも日常的に用いられている。例えば、アルミニウム反応剤はプロスタグランディン合成に、アミド化ホウ素触媒は、いくつかの医薬品プロセス合成に、バナジウム触媒は工業的規模での不斉酸化に用いられている。

私たちの有機合成への貢献は、基本的で、オリジナルな「分子性酸触媒」設計の概念を世界に先駆けて提唱、その有効性を内外に実証した。提案した「分子性酸触媒」の諸概念は全て世界初の提案で、その独創性・有効性は高い。

略歴

昭和42年3月
京都大学工学部工業化学科卒
昭和46年3月
米国ハーバード大学大学院博士課程修了 Ph. D.

職歴

昭和46年6月
東レ株式会社基礎研究所研究員
昭和47年4月
京都大学工学部助手
昭和51年10月
同大学講師
昭和52年9月
ハワイ大学淮教授
昭和55年4月
名古屋大学工学部講座担当助教授
昭和58年4月
同大学教授(平成15年 名誉教授)
平成14年7月
シカゴ大学化学教室教授(平成24年7月 名誉教授)
平成23年7月
中部大学教授 分子性触媒研究センター長

学術論文は>540報(引用2.8万回)、 総説は>130報、著書>10冊にあげられ、hインデックスは >91(雑誌のみ>97)。受賞および受章:IBM科学賞1988 服部報公賞1991 中日文化賞1992 プレログメダル1993 メルクシューハルト賞1994 日本化学会賞1995 東レ科学技術賞1997 マックス・ティシュラー賞1998 フランス化学会賞2002 テトラへドロンチェアー2002 紫綬褒章2002 分子不斉賞2003 AAAS フェロー2003 山田賞2004 テトラへドロン賞2006 カールチーグラー賞2006 学士院賞2007 フンボルト賞2007 日本化学会名誉会員2008 アメリカ化学会創造賞2009 有機合成化学特別賞2009 アメリカ学士院会員2011 野依賞2011 藤原賞2012 ロジャー・アダムス賞2017

Research Accomplishment of Professor Hisashi Yamamoto

Professor Yamamoto is an internationally recognized scholar whose contributions to organic chemistry span a wide range: from articulating and demonstrating new concepts of acid catalysis, to elucidating the stereochemical foundations of organic reactions, and to the creative invention of powerful new synthetic methods and their applications.  His distinctive contributions to all of these endeavors are characterized by originality and creativity.  The breadth of his research accomplishments reflects an intellectual virtuosity in the application of chemical principles to important synthetic and mechanistic problems.  His most important contributions are summarized that highlight both the scope and depth of his accomplishments over the past 45 years.  Most noteworthy of these numerous achievements are the novel aspects of Lewis and Brønsted acid catalysts he has brought to light in selective organic synthesis.  During his career he has discovered a wide variety of powerful new synthetic reactions, reagents, and catalysts based on acid catalysis. Through his dedicated efforts, Lewis and Brønsted acid are now recognized as major tools in the synthesis of both simple and complex organic molecules. Among Yamamoto's many superb contributions the following are especially worthy of mention.

 

   Asymmetric catalysis for C-C bond formation by chiral Lewis acids and Brønsted acids:

   In what is likely to become his most significant chemical legacy, Yamamoto has formulated a new paradigm for the chiral catalysis of reactions of main group elements by demonstrating chiral Lewis acid and/or Brønsted acid catalyzed asymmetric processes.  In the early 1980s, he first introduced chiral binaphthol as a key ligand for chiral Lewis acid catalysts. This work was the forerunner of a vast quantity of present-day research on the C2 symmetry based chiral Lewis acid catalyst, now known as privileged ligands.  Based on his knowledge of organoaluminum chemistry, he designed an organoaluminum catalyst for asymmetric hetero-Diels-Alder reaction in 1988.  It was his Brønsted acid-Lewis acid combined system, however, which offered him a unique opportunity as the most efficient asymmetric carbon-carbon formations based on Lewis acid catalyst.  Thus, his discovery of tartaric acid based catalyst (CAB catalyst) and amino acid based catalyst (oxaborolidine-type catalyst) led to the first and the most general enantioselective Diels-Alder reaction of a broad range of dienes and dienophiles. The same catalyst was shown to be the first one efficient for asymmetric aldol, ene, and allylation reactions.  His recently uncovered silver catalyzed aldol and allylation process has provided a new entry to the creation of a quaternary carbon stereogenic center for asymmetric synthesis.   A similar concept was employed for his catalytic asymmetric protonation under acidic conditions, which is capable of creating a long sought proton whichinduced asymmetric and biomimetic polyene cyclization.   The use of 8-hydroxyquinole based chiral Lewis acid catalysis was his recent contribution to acid catalysis.  The catalyst is designed as a rigid metal complex of cis-β-configuration, which makes the metal center of C1 chirality.  The ligand turned out to be a brand new "privileged ligand" for asymmetric synthesis: catalytic asymmetric pinacol coupling, NH reaction, Mukaiyama-Michael addition, Pudovik reactions, Strecker reaction, hydrocyanation, Nagata-Michael addition, and Nitroso-Diels-Alder reaction are now able to proceed with complete enantioselectivity.  In fact, most of theasymmetric carbon-carbon bond formation processes recognized today arebased on Yamamoto’s early discoveries.     

   Even more recently, he designed several chiral Brønsted acid catalysts with high reactivity for various asymmetric transformations.  The original Akiyama-Terada catalyst is able to only nitrogen molecules.  However, his phosphoramide catalyst could activate oxygen molecules and greatly expand the utility of the catalyst.  This field of chemistry is now growing rapidly and he is the pioneer of this important area of chiral super Brønsted acid catalysis.

 

General foundation of acid catalysis:

   Professor Yamamoto's contribution to organic chemistry is not limited to asymmetric synthesis.  However, the above contribution to asymmetric acid catalysis was based on his pioneering study in Lewis acid reagents. He was intrigued by the chemistry of the carbonyl compound-Lewis acid complex and introduced the unusually bulky organoaluminum reagents, methylaluminum bis(2,6-di-tert-butyl-4-methylphenoxide) (MAD) and aluminum tris(2,6-diphenylphenoxide) (ATPH). These reagents were successfully utilized for the selective alkylation of cyclic ketones and aldehydes to generate equatorial alcohol and an anti-Cram type product, respectively, for trans- and cis-selective Claisen rearrangement, for regioselective and exo-selective Diels-Alder reaction, and for epoxide-aldehyde rearrangement. The ATPH-aromatic carbonyl complex reacts with nucleophiles selectively at the para-position of the aromatic ring to generate cyclohexadiene derivatives. Besides these unexpected contributions to Lewis acid chemistry, his research in the area of organoaluminum chemistry has had a great impact on synthetic organic chemistry. The strong Lewis acidity of organoaluminum compounds appears to account for their strong tendency to form a stable 1:1 complex. Thus, the coordination of Lewis acid to molecules invariably causes a change of reactivity, and though coordinated by Lewis acid the group may be activated or deactivated depending upon the type of reaction. Furthermore, with the coordination of organic molecules an auxiliary bond can become coupled to the reagent and promote the designed reaction. In short, the reagents make a combined Lewis acid-Lewis base attack on a substrate with less activation energy, a field opened by Yamamoto's early and highly original studies which began in 1973. His aluminum amide reagents for epoxide rearrangement, biogenetic-type terpene synthesis, and the Beckmann rearrangement-alkylation reaction sequence are notable examples. Even more recently, Lewis acid coordinated heterocyclic compounds are able to activate the specific position of the molecule for CH activation which originated Yamamoto’s Lewis acid chemistry. Based on these careful investigations of selective Lewis acid/Lewis base complexation, he proposed several basic principles for acetal chemistry, which are now used in the selective ring opening and alkylation processes for modern organic synthesis. 

   Direct condensation of carboxylic acids by alcohols or amines is the most important transformation of organic synthesis. Yamamoto found Lewis acid catalyst could play an important role in esterification and amidation processes. For example, his zirconium- or hafnium-catalyzed esterification and boron-catalyzed amidation are ground-breaking studies.    

   Finally, using this crucial information of Lewis acid and Brønsted acid catalysis, he recently achieved super silyl (tris(trimethylsilyl)silyl) chemistry which can realize double or triple aldol reaction in a single pot to generate a number of stereogenic centers in the molecule. Otherwise unattainably high diastereoselectivity in this cascade reaction makes this process a so-called "second generation of Mukaiyama aldol reaction", which can make up to aneleven hydroxyl polyketide structure in three steps in a stereospecific manner.  These findings open a possibility for a polyketide synthesizer, heretofore only dreamed of.

 

   Other catalytic asymmetric transformations:

   Professor Yamamoto also contributes significantly in the area of catalytic asymmetric oxidation reactions.  For example, the nitroso-aldol reaction originated from his invention of 10 years ago.  And asymmetric homo and bisohomoallylic alcohol was achieved in his laboratory for the first time.  His tungsten chemistry is a real ground breaking discovery for oxidation using this non-toxic metal catalyst.  Sequential epoxidation/ring opening will be used for a new strategy to generate >99.9%ee of the amino alcohol synthesis.  The following is a list of catalytic asymmetric processes developed by Professor Yamamoto: O-nitro aldol and N-nitroso aldol synthesis; Nitroso-Diels-Alder reaction; epoxidations of homoallylic, and bishomoallylic alcohol; Asymmetric SN2 cross coupling with carbonyl and allylic nucleophiles. All of these reactions are unique and robust for modern organic synthesis.

 

   Professor Yamamoto haspublished over 540 papers and over 135 reviews (50 inJapanese) which have been cited >28,000 times with anh-index of 91 ( for papers alone) and >95 including reviews and books.

 

   His contributions have been recognized by his being a recipient of, among others: the Prelog Medal (1993), the Chemical Society of Japan Award (1995), Le Grand Prix de la Fondation Maison de la Chimie (2002), National Prize of Purple Medal (Japan) (2002), the Tetrahedron Prize for Creativity in Organic Chemistry (2006), the Japan Academy Award (2007), Grand Prize of Synthetic Organic Chemistry of Japan (2009), the ACS Award for Creative Work in Synthetic Organic Chemistry (2009), Fellow of American Academy Arts and Science (2011), Noyori Prize (2011) and Fujiwara Prize (2012).

 

   Selected publications (Yamamoto):

[1] Asymmetric cyclization of unsaturated aldehydes catalyzed by a chiral Lewis acid. Tetrahedron Lett, , 26, 5535, (1985). [2] Asymmetric hetero-Diels-Alder reaction catalyzed by chiral organoaluminum reagent. J. Am. Chem. Soc., 110, 310 (1988). [3] Acyloxyborane: An activating device for carboxylic acids. J. Am. Chem. Soc., 110, 6254 (1988) [4] Designer Catalysis: Combined Acid Catalysis for Asymmetric Synthesis. Angew. Chem. Int. Ed. 44, 1924-1942 (2005). [5] Oxazaborolidine-Derived Lewis Acid Assisted Lewis Acid as a Moisture-Tolerant Catalyst for Enantioselective Diels–Alder Reactions. Angew. Chem. Int. Ed. Enl., 44, 1484-1487 (2005).  [6] Brønsted Acid Catalysis of Achiral Enamine for Regio- and Enantioselective Nitroso Aldol Synthesis. J. Am. Chem. Soc., 127, 1080 (2005). [7] Design of Chiral N-Triflyl Phosphoramide as a Strong Chiral Brønsted Acid and its application to Asymmetric Diels-Alder Reaction, J. Am. Chem. Soc. 128, 9626 (2006). [8] Asymmetric Conjugate Addition of Silyl Enol Ethers Catalyzed by Tethered Bis(8-Quinolinolato) Aluminum Complexes, J. Am. Chem. Soc. 129, 742-743, (2007). [9] Regioselective and Asymetric Diels-Alder Reaction of 1- and 2-Substituted Cyclopentadienes Catalyzed by a Brønsted Acid Activated Chiral Oxazaborolidine, J. Am. Chem. Soc., 129, 9536-9537 (2007). [10] Catalytic Enantioselective Pudovik Reaction of Aldehydes and Aldimines with Tethers Bis(8-quinolinato) (TBOx) Aluminum Complex. J. Am. Chem. Soc., 130, 10521-10523 (2008). [11] Cationic-Oxazaborolidine-Catalyzed Enantioselective Diels-Alder Reaction of ,β-Unsaturated Acetylenic Ketones. Angew. Chem. Int. Ed., 48, 8060-8062 (2009). [12] Dual-Activation Asymmetric Strecker Reaction of Aldimines and Ketimines Catalyzed by a Tethered Bis(8-quinolinolato) Aluminum Complex. J. Am. Chem. Soc., 131, 15118-15119 (2009). [13] Lewis Acid Catalyzed Inverse-Electron-Demand Diels-Alder Reaction of Tropones. J. Am. Chem. Soc., 131, 16628-16629 (2009). [14] Rapid and Stereochemically Flexible Synthesis of Polypropionates: Super-Silyl-Governed Aldol Cascades. Angew. Chem. 124, 1978–1982 (2012).  [15] Ten Years Research in Chicago, Tetrahedron, 69, 4503-4515 (2013).  [16] Tungsten catalyzed oxidation and ring opening to generate >99.9%ee product, J. Am. Chem. Soc., 136, 1222-1225 (2014). [16] Nickel-​Catalyzed Regio- and Enantioselective Aminolysis of 3,​4-​Epoxy Alcohols, Wang, C.; Yamamoto, H.,  J. Am. Chem. Soc., 137, 4308-4311 (2015). [17] Chiral Bronsted Acid as a True Catalyst: Asymmetric Mukaiyama Aldol and Hosomi-​Sakurai Allylation Reactions, Sai, M. Yamamloto, H., J. Am. Chem. Soc., 137,7091-7094 (2015). [18] Gadolinium-​Catalyzed Regio- and Enantioselective Aminolysis of Aromatic trans-​2,​3-​Epoxy Sulfonamides, Wang, C.; Yamamoto, H., Angew. Chem. Int. Ed., 54, 8760-8763 (2015).  [19] Catalytic Enantioselective Nitroso Diels-Alder Reaction, Maji, B.; Yamamoto, H., J. Am. Chem. Soc., 137, 15957-15963 (2015).  [20] Design of a New Bimetallic Catalyst for Asymmtric Epoxidation and Sulfoxidation, Bhadra, S., Akakura, M.; Yamamoto, H., J. Am. Chem. Soc., 137, 15612-15615. (2015)

CURRICULUM VITAE of Hisashi Yamamoto

Professor and Director, Molecular Catalyst Research Center, Chubu University

Professor Emeritus, The University of Chicago

Professor Emeritus, Nagoya University

Personal Data

Born: July 16, 1943 (Kobe, Japan)

Citizenship:  Japan

Current Address:                      Chubu University, Molecular Catalyst Research Center

                                                1200 Matsumoto, Kasugai, 487-8501 Japan

                                                +81 568 51 9440 , home: +81 52 217 1984 cell: +81 90 9129 1867

                                                hyamamoto@isc.chubu.ac.jp

                         The University of Chicago, Department of Chemistry

                                                5735 South Ellis Avenue, Chicago, IL 60637, USA

                                                yamamoto@uchicago.edu                                                     

Education

                B. S.                        Kyoto University, 1967 (Prof. H. Nozaki, Thesis Director)

                Ph. D.                      Harvard University, 1971 (Prof. E. J. Corey, Thesis Director)

Professional:

                1971-1972               Researcher, Toray Industries, Inc. (Prof. J. Tsuji, Adviser)

                1972-1976               Instructor, Kyoto University (Prof. H. Nozaki, Adviser)

                1976-1977               Lecturer, Kyoto University

                1977-1980               Associate Professor, University of Hawaii

                1980-1983               Associate Professor, Nagoya University

                1983-2002               Professor, Nagoya University

                2003-                       Professor Emeritus, Nagoya University

                2002-2012               Professor, The University of Chicago

                2012-                       Professor Emeritus, The University of Chicago

                2012-                       Professor and Director of Molecular Catalyst Research Center, Chubu University

                2012-                       Research Supervisor, JST Crest Project of Molecular Technology

                2014-                       Research Supervisor, JST-ANR Joint Project of Molecular Technology

                2016-2018               President of Chemical Society of Japan

Publication

                >540 original papers and >140 reviews

h-index: 91 (Web of Science, only for journal), 97 (Google, with books), citation: 44527 (Google); 28000 (web of science)

Membership

                The American Chemical Society, American Academy of Arts and Sciences

                American Association for the Advancement of Science, The Chemical Society of Japan

                The Pharmaceutical Society of Japan, The Society of Synthetic Organic Chemistry, Japan

                The Royal Society of Chemistry, London, Kinki Chemical Society, Japan

                The Engineering Society of Japan         

Editorship              

                Organic Syntheses, Board of Editors, 1988-1993, Advisory Board,1993-present

                Synlett, Board of Editor, 1989-

                Tetrahedron: Asymmetry, Consulting Editor, 1990-

                J. Am. Chem. Soc., Editorial Advisory Board, 1994-1999

                J. Chem. Soc., Chem. Commun., Regional Advisory Board, 1994-1996

                Bull. of the Korean Chemical Society, International Advisory Board, 1998-2005

                Organic Letters, Advisory Board, 1999-presnt

                Journal of Oleo Science, Editorial Advisory Board, 2001-

                European Journal of Organic Chemistry, Advisory Board, 1999-

                Encyclopedia of Reagents for Organic Synthesis, International Advisory Board, 1992-1995

                Molecules Online, Springer, 1998-1999

                Topics in Current Chemistry, Springer, Board Member,1997-2014

                Advanced Synthesis & Catalysis, Advisory Board, 2001-2011

                Synfacts, Board of Editor, 2002-2014

                Central European Science Journals, Advisory Board, 2002-

                Tetrahedron and Tetrahedron Letters, Advisory Board, 2002-

                Bulletin of the Chemical Society of Japan, Editorial Advisory Board, 2005-

                Chemistry – An Asian Journal, International Advisory Board, 2006-

                Chemistry Letters, Advisory Board, 2010-

                The Chemistry Record, Editor in Chief, 2010-

Academic Awards and Honors:

                The Chemical Society of Japan Award for Young Chemist, 1977. 

                IBM Science Award, 1988,  Houkou Award, 1991,  Chunichi Award, 1992.

                Prelog Medal, 1993,  Merck-Schuchardt Lectureship, 1994.

                The Chemical Society of Japan Award, 1995.  Toray Science and Technology Award, 1997

                Max-Tishler Prize, 1998,  Le Grand Prix de la Fondation Maison de la Chimie, 2002,

                Tetrahedron Chair, 2002.  Medal of Honor with Purple Ribbon (Japan), 2002

       Molecular Chirality Award, 2003, Fellow of American Association for the Advancement of Science, 2003,          Yamada Prize, 2004, Tetrahedron Prize, 2006, The Karl-Ziegler Professorship, 2006,

         The Japan Academy Award, 2007,  Humboldt Research Award, 2007,

         Honorary Member of the Chemical Society of Japan, 2008

               ACS Award for Creative Work in Synthetic Organic Chemistry, 2009

                Grand Prize of Synthetic Organic Chemistry of Japan, 2009

                Member of American Academy of Arts and Sciences, 2011,

                Noyori Prize, 2011,Fujiwara Prize, 2012

Plenary and Name Lectures (International):

1979         Pacific Coast Lecturer, USA

1979         PAC Meeting, Honolulu, USA

1982         IUPAC Conference on Organic Synthesis, Tokyo

1983         IUPAC Conference on Organometallic Chemistry Directed Toward Organic Synthesis, France

1984         Annual Meeting of Pharmaceutical Society of Japan, Tokyo

1985         Euchem Stereochemistry Conference at Burgenstock, Switzerland

1985         Annual Meeting of Chemical Society of Japan, Tokyo

1986         Annual Meeting of Chemical Society of Korea, Seoul

1986          Gordon Conference on Stereochemistry, USA

1986         Hoechst Conference on Stereochemistry, Germany

1987         Annual Meeting of Agricultural Society of Japan, Tokyo

1987          IUPAC Conference on Organometallic Chemistry Directed Toward Organic Synthesis,

                 Canada

1987         Organic Synthesis Lecturer, University of California, Berkeley

1987         Syntex Distinguished Lecturer, Colorado State University

1987         Sheffield Stereochemistry Symposium, UK

1987         Western Switzerland 3e Cycle Lecturer

1988         Karl Pfizer Visiting Professor, MIT

1988         First Organic Reaction Lecturer, USA

1988         IUPAC Conference on Natural Product, Kyoto

1988         NATO Conference on Stereochemistry, Greece

1988         International Symposium of Acid-Base Catalysis, Sapporo

1989         Annual Meeting of Chemical Society of Japan, Kyoto

1989         Visiting Professor of Universite Louis Pasteur, Strasbourg

1989         11th International Symposium of Synthesis in Organic Chemistry, Oxford, UK

1989         Progress and Prospects in Organic Synthesis, Lausanne and Champery, Switzerland

1989         PAC Meeting, Honolulu

1990         Fifth Japan-Korea Seminar on Organic Chemistry, Dae Jeon , Korea

1990         The American Chemical Society, Aldrich Award Symposium, Boston

1990         Midwestern Distinguished Lecturer, USA

1990         Third Belgian Organic Synthesis Symposium, Louvain-La-Neuve, Belgium

1990         Eighth International IUPAC Conference on Organic Synthesis, Helsinki, Finland

1990         The Second International Symposium on the Chemical Synthesis of Antibiotics and

                 Related Microbial Products, Oiso, Japan

1990         Annual Meeting of Chemical Society of Japan, Hiroshima

1990         Special Symposium of Pharmaceutical Society of Japan, Tokyo

1991         Annual Meeting of Pharmaceutical Society of Japan, Tokyo

1991         Symposium of Ohio State University, Recent Advances in Asymmetric Synthesis, USA

1991         Syntex Distinguished Lecturer at University of Colorado, Boulder, USA

1991         First Anglo-Norman Organic Chemistry Colloquium, Rouen, France

1991         Japan-US Seminar, Selectivity in Synthetic and Bioorganic Chemistry, Tokyo

1991         Otuka Symposium on Asymmetric Reactions and Molecular Recognition, Tokushima

1991          The 1991 Josef Fried Symposium of Bioorganic Chemistry, Chicago

1992          Annual Chemical Congress of the Royal Society of Chemistry, Manchester

1992          Nozaki Conference, Yokohama

1992          Gordon Conference (Organic Reaction Mechanism), New Hampton School

1992          7th International Symposium on Molecular Recognition and Inclusion, Kyoto

1992          6th Japan-Korea Organic Chemistry Symposium, Nagoya

1992          First International Symposium on Organic Synthesis, Tokyo

1992          7th Johnson Symposium, Stanford, CA.

1992          International Symposium on Inorganic and Organic Chemistry, Taipei, Taiwan

1992          Tsing-Hua Symposium on Organic and Inorganic Chemistry, Hsinchu, Taiwan

1993          Annual Meeting of Chemical Society of Japan, Tokyo

1993          Bader Symposium, Harvard University, Cambridge, USA

1993          Gordon Conference (Natural Product), New Hampton School, USA

1993          Fourth International Symposium on Chiral Discrimination, Quebec, Canada

1993          Prelog Medal Lecture, Zurich, Switzerland

1994          Annual Meeting of New Swiss Chemical Society, Switzerland

1994          Merck-schuchardt Lectureship, Germany

1994          The 4th International Conference on Chemical Synthesis of Antibiotics and                                                                 related Microbial Products, Nashville, USA

1994          Pre-IUPAC International Symposium on Metal-Mediated Organic Synthesis, India

1995          Annual Meeting of Chemical Society of Japan, Tokyo

1995          Merck-Frosst Lecturer, Alberta University, Canada

1995          Enantioselective C-C bond formation in synthesis, SCI, London, UK

1995          SFC-Rhone Poulene Lecturer, France

1996          Organic Synthesis Lecturer, University of California, Irvine

1996          Annual Conference of Polymer Science, Nagoya, Japan

1996          50th Anniversary Conference of Korean Chemical Society, Seoul, Korea

1996          Fargo Conference on Main Group Chemistry, North Dakota, USA

1996          ISCHIA Advanced School of Organic Chemistry, Ischia, Italy

1997          Gilbert Stork Lecturer, Columbia University, New York, USA

1997          H.C. Brown Lecturer, Purdue University, USA

1997          36th IUPAC Congress, Geneva, Switzerland

1997          9th International Symposium on Chiral Discrimination, Nagoya, Japan

1997          William G. Dauben Lecturer, University of California, Berkeley, USA

1997          Bio-Mega Lecturer, Montreal, Canada

1997          5th Max Tishler Memorial Symposium, Tokyo

1998          Max Tishler Prize Lecture, Harvard, USA

1998          1998 Hofmann Distinguished Lecture, Imperial College, London, UK

1998          12th IUPAC Conference on Organic Synthesis, Venice, Italy

1998           9th International Symposium on Novel Aromatic Compounds, Hong Kong

1999           Novartis Lectureship, Switzerland

1999          37th IUPAC Congress, Berlin, Germany

1999          218th National meeting of American Chemical Society, New Orleans, USA

2000        Taiwan National Lectureship, Taiwan

2000          Columbia IAP Lecturer, USA

2000          Kharasch Lecturer, University of Chicago, USA

2001          PAC meeting, Honolulu, USA

2001          UCSD-Dupont symposium, La Jolla, USA

2001          84th CSC Conference, Montreal, Canada

2001         Annual Meeting of Chemical Society of Japan, Chiba, Japan

2001         ICCOC-GTL-10, Bordeaux, France

2002         The Nagoya COE-RCMS Conference, Japan

2002         Cram Stereochemistry Symposium, UCLA, USA

2002         BOSS IX Meeting, Namur, Belgium

2002         Gordon Conference, Reaction and Processes, RI, USA

2002         Oppolzer Lectures 2002, Genève, Switzerland

2003         Otto-Bayer Lecturer 2003, Cologne, Germany

2003         15th International Symposium on Chirality, Shizuoka, Japan

2003         18th International Symposium on Synthesis in Organic Chemistry, Cambridge, U. K.

2003         Komppa Centenary Symposium, Espoo, Finland

2003         Boehringer Ingelheim Lecturer, Alberta, Canada

2004         The 17th Annual Organic Chemistry Day, Missouri, USA

2004         2004 CU-Roche Colorado Symposium on Synthetic Organic Chemistry, Boulder, Colorado

2004         10th Meeting of the French-American Chemical Society, Charleston, SC

2004         CMDS Symposium, Seoul, Korea  

2004         The Fourth International Symposium on Chemistry and Biological Chemistry of Vanadium,

                  Szged, Hungary

2004         Pettit Centennial Lecturer, University of Texas

2004         Merck Lecturer, University of Puerto Rico

2005         Pfizer Lecturer, Harvard University

2005         125th Annual Meeting of Pharmaceutical Society in Japan 

2005         Distinguished Merck Frosst Lectureship, Canada

2005         Novartis Lecturer, University of Illinois at Urbana-Champaign

2005         OMCOS-13, Genève, Switzerland

2005         The 22nd Summer Seminar on Synthetic Organic Chemistry, Japan

2005         Eli Lilly Lecturer, University of Pittsburg

2005         International SFB-Symposium, Aachen, Germany

2005         The 4th COE-Chem6 International Symposium, Tokyo, Japan

2005         PAC Meeting, Inorganic and Polymer sections, Honolulu, USA

2005         PAC Meeting, Polymer Chemistry, Honolulu, USA

2006         COE meeting, Nagoya University, Nagoya Japan

2006         Reilly Lecturer, University of Notre Dame

2006         7th Annual Florida Heterocyclic Conference, Gainesville, USA

2006         Appleton Lecturer, Brown University, USA

2006         Eli Lilly Lecturer, Yale University, USA

2006         Challenges in Contemporary Chemistry Symposium, University of Michigan

2006         Banyu Symposium, Fukuoka, Japan

2006         Balticum Orgnicum Syntheticum, Tallinn, Estonia

2006         Organocatalysis in Organic Synthesis, Glasgow, UK

2006         FrontChem2006, Zushi, Japan

2006         American Chemical Society, National Meeting, San Francisco

2006         5th International Symposium on Chemistry and Biological Chemistry of Vanadium,

                  San Francisco

2006         Inaugural Negishi-Brown Lecture, Purdue

2006         Merck-Frosst Lecture, Univdersite de Montreal, Canada

2006         Novartis Lecturer, Boston College, Boston

2006         Karl-Ziegler-Professorship, Max Planck Institute, Germany

2006         6th Tateshina conference on Organic Chemistry, Tateshina, Japan

2006         10th International Kyoto conference on New Aspects of Organic Chemistry, Japan

2006         Pierre Fabre Lecturer, French Chemical Society, Paris, France

2007         American Chemical Society, National Meeting, Chicago

2007         Organic Chemistry, present and future, Louvain-la-Neuve, Belgium

2007         International Conference on Asymmetric Organocatalysis, Otsu, Japan

2007         The 29th annual Princeton ACS Fall Organic Symposium, Princeton

2007         Invited Lecture Series, Academy of Science of the Czech Republic

2007         The 5th Kitasato Chemistry Symposium, Tokyo

2007         Organic Synthesis Mini Symposium, Chiba

2007         The Japan Academy Prize Symposium, Riken, Japan

2008         Schulich Symposium on Asymmetric Catalysis, Haifa, Israel

2008         Roche Distinguished Lecturer, Colorado

2008         Bristol-Myers Squibb Lecturer, Berkeley

2008         Eli Lilly Lecturer, University of Toronto

2008         FITS Symposium, Geneva, Switzerland

2008         Banyu Foundation Symposium, Sapporo, Japan

2008         Suzuki Kunio Symposium, Tokyo, Japan

2008         Tarrant visiting professor of organic chemistry, University of Florida

2008         International Conference on Asymmetric Catalysis, Kanazawa, Japan

2008         Lecturer of Institute of Academia Sinica, Taipei

2009         LOST II, Alain Krief Symposium, Namur, Belgium  

2009         Chicago Organic Chemistry Symposium, Northwestern University

2009         The Third Novel Chiral Chemistry, Japan 2009, Tokyo

2009         The Lambert Lecture, Boston University

2009         The Gilman Lecturer, Iowa State University

2009         The Roche Lecturer, Scripps Institute, USA

2009         Tetrahedron Symposium, Paris

2009         Nanyang Tec. University Opening Symposium, Singapore

2009         ACS meeting, Milwaukee, WI

2009         13th Asian Chemical Congress, Shanghais, China

2009         The H. Smith Broadbent Lecture, BYU, Salt Lake

2009         Eminent Scholar Lecturer, The University of Arizona, Tucson

2009         KISPOC, Kyushu, Japan

2010         The Chemical Record Lecturer, Osaka, Japan

2010         The AkzoNobel, Novartis and Shasun Lecture, Bristol, UK

2010         Burgenstock Conference, Guest of Honor, Brunnen, Switzerland

2010          N. C. Yang Lecturer, Taipei

2010         93rd Canadian Chemistry Conference, Toronto, Canada

2010         ISOm, Organocatalyst Symposium, Muelheim, Germany

2011         Frontier in Chemical Research Lecturere, Texas A&M

2011         19th Lilly symposium, Madrid, Spain

2011         Gassman Lectureship, University of Minnesota, Minneapolis

2011         First Mexican Meeting on Pure and Applied Chemistry, Mexico City

2011         42nd National Organic Symposium, Princeton

2011         European Science Foundation, COST conference, Maratea, Italy

2011         Ei-Ichi Negishi Nobel Prize Symposium, Purdue, IN

2011         First Germany-Japan Organocatalytic Symposium, Kyoto, Japan

2012         Abbott Lecture, Yale University, New Haven

2012         Vertex Lecture, UCIrvine

2012         Natural Product Symposium, Kyushu, Japan

2012         4th EurCheMS, Prague, Czech

2012         BMS Lecture, Boston College

2012         Roche Lecture, Columbia University

2013         International Conference of Catalysis, Cologne

2013         25th Banyu Symposium, Sappro, Japan

2013         International Conference, Prague

2014         Academia Sinica, Taipei

2014         Gordon Conference, USA

2014         International Conference of Catalysis, Chicago, USA

2015         Tetrahedron Symposium, Tokyo, Japan

2015         WPI Lecture, Tohoku University, Japan

2015         Kanagawa symposium, Kanagawa, Japan

2015         Riken Symposium, Saitama, Japan

2015         Naito Symposium, Sapporo, Japan

2015         Negishi-Brown Lecturer, USA

2015         ELP Lectureship, Kyoto University

2015         IKOCK Symposium, Alkara, Spain

2015         Pachifichem 2015, Honolulu, USA

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